Adversaries may communicate using OSI application layer protocols to avoid detection/network filtering by blending in with existing traffic. Commands to the remote system, and often the results of those commands, will be embedded within the protocol traffic between the client and server.
Adversaries may utilize many different protocols, including those used for web browsing, transferring files, electronic mail, or DNS.
This type of attack technique cannot be easily mitigated with preventive controls since it is based on the abuse of system features.